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DTSTART:20190331T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260403T220525Z
UID:1568642400@ist.ac.at
DTSTART:20190916T160000
DTEND:20190916T170000
DESCRIPTION:Speaker: Eve Marder\nhosted by Maximilian Jösch\nAbstract: Exp
 erimental work on the crustacean stomatogastric ganglion (STG) has reveale
 d a 2-6 fold variability in many of the parameters that are important for 
 circuit dynamics. Theoretical work shows that similar network performance 
 can arise from diverse underlying parameter sets. Together\, these lines o
 f evidence suggest that each individual animal\, at any moment in its life
 -time\, has found a different solution to producing “good enough” moto
 r patterns for healthy performance in the world. This poses the question o
 f the extent to which animals with different sets of underlying circuit pa
 rameters can respond reliably and robustly to environmental perturbations 
 and neuromodulation. We use both experimental and computational methods to
  study the effects of temperature\, pH\, high K+ concentrations\, and neur
 omodulation on the networks of the STG from the crab\, Cancer borealis. Wh
 ile all animals are remarkably robust and reliable to substantial perturba
 tions\, extreme perturbations produce "crashes". These crashes vary substa
 ntially across the animal and in models with different underlying paramete
 r differences. The idiosyncratic nature of the crashes provides heuristic 
 insight into the diverse nature of individuals to extreme perturbations. M
 oreover\, models of homeostatic regulation of intrinsic excitability give 
 insight into the kinds of mechanisms that could give rise to the highly va
 riable solutions to stable circuit performance. The underlying parameter d
 ifferences across the animals in a population and their differences in cra
 sh behavior provide a necessary substrate for evolution.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Eve Marder: Differential Resilience to Perturbation of Circuits wit
 h Similar Performance
URL:https://talks-calendar.ista.ac.at/events/1166
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