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DTSTAMP:20260405T192126Z
UID:1578927600@ist.ac.at
DTSTART:20200113T160000
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DESCRIPTION:Speaker: Erich Bornberg-Bauer\nhosted by Fyodor Kondrashov\nAbs
 tract: Proteins come at a most amazing diversity of structures and functio
 ns: they perform transportation (e.g. haemoglobin)\, provide stability (cy
 toskeleton or muscles)\, harvest energy (photosynthesis) and confer signal
 s (cell division) in all organisms. No proteins\, no life. Rational and ir
 rational lab based as well as computational techniques have tried for deca
 des now to create proteins with desired properties but with meager success
  at best. Also\, how evolution accomplished protein diversity\, is largely
  unclear\, after many decades of research. This lack of knowledge hampers 
 further progress in exploiting evolutionary strategies for designing new p
 roteins since\, for example\, directed evolution gets easily stuck due to 
 constraints imposed by historic contingencies of the starting material. We
  therefore address two fundamental questions: (i) how did enzymes change t
 heir relative functionalities (i.e. dominant vs. promiscous sub-dominant a
 ctivities) during evolution and (ii) is it possible to generate completely
  new\, functional proteins out of random amino-acid sequences. For the for
 mer we use phylogenies\, ancestral sequence reconstruction and novel surfa
 ce display methods in combination with droplet assays to screen billions o
 f mutants from large libraries within hours. For the latter we reconstruct
  the history of how novel proteins were borne out from random DNA and beca
 me functional without selection and adaptation of their structural propert
 ies. Together\, our methods will open new avenues for protein design which
  can overcome (at least some of the) hurdles imposed by earlier\, more dir
 ected strategies.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Erich Bornberg-Bauer: Breeding new proteins\, the evolutionary way
URL:https://talks-calendar.ista.ac.at/events/1150
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