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TZID:Europe/Vienna
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DTSTART:20200329T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260404T110044Z
UID:1573484400@ist.ac.at
DTSTART:20191111T160000
DTEND:20191111T170000
DESCRIPTION:Speaker: Adrian Bird\nhosted by Gaia Novarino\nAbstract: Cytosi
 ne residues in DNA can be modified post-synthetically and this affects loc
 al protein-DNA interactions. For example\, the MeCP2 protein specifically 
 binds to methylated sites in the genome\, potentially allowing it to inter
 pret this epigenetic mark. Several clinical disorders are caused by mutati
 ons in the MECP2 gene\, including the profound neurological disorder Rett 
 syndrome. The equivalent phenotype in animal models can be reversed\, sugg
 esting that the protein fine-tunes neuronal function and that the human di
 sorder may also be curable. Evidence will be presented that the root cause
  of Rett syndrome is failure of the primary function of MeCP2\, which is t
 o restrain gene expression in a DNA methylation-dependent manner.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Adrian Bird: Reading DNA methylation in the brain
URL:https://talks-calendar.ista.ac.at/events/1144
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