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DTSTAMP:20260404T203400Z
UID:1572879600@ist.ac.at
DTSTART:20191104T160000
DTEND:20191104T170000
DESCRIPTION:Speaker: Edward Boyden\nhosted by Graduate Student and PostDoc 
 Associations\nAbstract: Understanding and repairing complex biological sys
 tems\, such as the brain\, requires new technologies that enable such syst
 ems to be observed and controlled with great precision\, across extended s
 patial and temporal scales. We are discovering new molecular principles th
 at are leading to such technologies. For example\, we recently discovered 
 that it was possible to physically magnify biological specimens manyfold\,
  in an even way\, by embedding them in dense swellable polymers\, mechanic
 ally homogenizing the specimens\, and then adding water to isotropically s
 well the specimens. In this method\, which we call expansion microscopy (E
 xM)\, we enable scalable\, inexpensive diffraction-limited microscopes to 
 do large-volume nanoscopy\, in a multiplexed fashion – important\, for e
 xample\, for brain mapping. As another example\, we discovered that microb
 ial opsins\, genetically expressed in neurons\, could enable their electri
 cal activities to be precisely driven or silenced in response to milliseco
 nd timescale pulses of light. These tools\, called optogenetic tools\, are
  enabling causal assessment of the contribution of defined neurons to beha
 viors and pathologies in a wide variety of basic science settings. Finally
 \, we have developed new methods of directed evolution\, and discovered mu
 tant forms of optogenetic tools that enable precision fluorescent imaging 
 of the high-speed voltage of neurons in the living brain. We share all the
 se tools freely\, and aim to integrate the use of these tools so as to lea
 d to comprehensive understandings of neural circuits.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Edward Boyden: Tools for analyzing and controlling complex biologic
 al systems
URL:https://talks-calendar.ista.ac.at/events/1143
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