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TZID:Europe/Vienna
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DTSTART:20190331T030000
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TZOFFSETTO:+0200
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260404T110159Z
UID:1571666400@ist.ac.at
DTSTART:20191021T160000
DTEND:20191021T170000
DESCRIPTION:Speaker: Jay T. Groves\nhosted by Martin Loose \nAbstract: Acti
 vation of T cell receptors (TCR) by agonist peptide major histocompatibili
 ty complex (pMHC) molecules is the front line of the adaptive immune respo
 nse.  T cells discriminate among different pMHC based on molecular bindi
 ng dwell time between pMHC and TCR\, and this discrimination is widely con
 sidered to utilize a kinetic proofreading mechanism.  After TCR activati
 on\, activated ZAP70 kinase at the TCR phosphorylates the scaffold molecul
 e\, LAT.  It has recently been realized that LAT undergoes a protein con
 densation phase transition on the membrane surface\, in a phosphorylation 
 dependent manner.  In this talk I will focus on the mechanism of LAT con
 densation and possible roles for this phase transition in the context of T
  cell signaling.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Jay T. Groves: Phase transitions and molecular timing in T cell sig
 naling
URL:https://talks-calendar.ista.ac.at/events/1141
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