BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20180325T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20181028T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260406T043410Z
UID:5a82cef95bf2c746707402@ist.ac.at
DTSTART:20180327T130000
DTEND:20180327T140000
DESCRIPTION:Speaker: Samuel M. Young\, Jr\nhosted by Peter Jonas\nAbstract:
  In mammalian central nervous system synapses\, the voltage-gated CaV2 Ca2
 + channels\, CaV2.1\, CaV2.2\, and CaV2.3 are the major source of Ca2+ ent
 ry for neurotransmitter release. Due to the steep Ca2+ dependence of neuro
 transmitter release\, the number of functional CaV2 channels and their pro
 ximity to synaptic vesicles (SVs) are key determinants of the strength and
  kinetics of neurotransmitter release that help define neural circuit outp
 ut. Furthermore\, developmental variations in these parameters can help re
 fine information encoding by the neuronal circuit. However\, we know littl
 e about the molecular mechanisms that regulate these CaV2 channel properti
 es at the synapse and throughout development. To elucidate these mechanism
 s\, we are taking a systematic approach and utilizing transgenic mouse mod
 els and novel viral vectors to manipulate Cav2 subtypes in vivo at the cal
 yx of Held presynaptic terminal during different developmental stages in c
 ombination with analysis using electrophysiology and electron microscopy (
 EM) methods. In this talk\, I will present our recent results on the regul
 ation of Cav2 subtype levels and their proximity to SVs in the presynaptic
  terminal\, as well as their impact on synaptic transmission.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:ekrallib@ist.ac.at
SUMMARY:Samuel M. Young\, Jr: Elucidating the molecular mechanisms that reg
 ulate voltage gated calcium channel subtypes levels and organization in th
 e presynaptic terminal
URL:https://talks-calendar.ista.ac.at/events/1133
END:VEVENT
END:VCALENDAR