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DTSTAMP:20260405T223631Z
UID:5a990e3b8e980331098860@ist.ac.at
DTSTART:20180417T133000
DTEND:20180417T143000
DESCRIPTION:Speaker: Oren Schuldiner\nhosted by Simon Hippenmeyer\nAbstract
 : In our laboratory\, we study the molecular mechanisms that regulate\, co
 ntrol and execute developmental neuronal remodeling in Drosophila melanoga
 ster. Remodeling refines neural circuits by a combination of degenerative 
 processes\, such as axon and synapse pruning\, as well as regenerative pro
 cesses\, such as regrowth to form adult specific connections. Neuronal rem
 odeling is essential for sculpting the mature nervous systems of both vert
 ebrates and invertebrates during development. Despite its fundamental role
  in neurodevelopment and proposed contribution to various neuropsychiatric
  disorders\, the mechanisms instructing remodeling are only partially know
 n. The stereotypical remodeling of the Drosophila mushroom body (MB) durin
 g metamorphosis provides a unique system to genetically dissect neuronal r
 emodeling. Here\, we uncover the fine temporal transcriptional landscape o
 f MB ? neurons throughout their remodeling phase. To enrich and complement
  this developmental expression atlas\, we also sequenced developing ? neur
 ons perturbed for three key transcription factors known to regulate prunin
 g. Together\, these datasets allowed us to construct the developmental and
  temporal framework of transcriptional modules that together drive remodel
 ing. Moreover\, we identified 10 DNA binding proteins that are involved in
  various aspects of remodeling\, and describe their hierarchical relations
 hips. Overall\, this study provides the first broad and detailed molecular
  insight into the complex regulatory dynamics of developmental neuronal re
 modeling.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:wkoelbl@ist.ac.at
SUMMARY:Oren Schuldiner: From genetics to system\, and back: A systematic e
 xploration of neuronal remodeling
URL:https://talks-calendar.ista.ac.at/events/1130
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