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DTSTART:20180325T030000
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DTSTART:20171029T020000
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DTSTAMP:20260424T040555Z
UID:5a7aa56f206eb984321351@ist.ac.at
DTSTART:20180226T144500
DTEND:20180226T160000
DESCRIPTION:Speaker: Benedikt Berninger\nhosted by Maximilian Jösch\nAbstr
 act: Ectopic expression of defined transcription factors can force direct 
 cell fate conversion from one lineage to another in the absence of cell di
 vision1. Several transcription factor cocktails have enabled successful re
 programming of various somatic cell types into induced neurons (iNs) of di
 stinct neurotransmitter phenotype2-5. However\, the nature of the intermed
 iate states that drive the reprogramming trajectory towards distinct iN ty
 pes is largely unknown. Here we show that successful direct reprogramming 
 of adult human brain pericytes into functional iNs by Ascl1 and Sox2 (AS) 
 encompasses transient activation of a neural stem cell-like gene expressio
 n program that precedes bifurcation into distinct neuronal lineages. Intri
 guingly\, during this transient state key signaling components relevant fo
 r neural induction and neural stem cell maintenance are regulated and func
 tionally contribute to iN reprogramming and maturation. Thus\, AS-mediated
  reprogramming into a broad spectrum of iN types involves the unfolding of
  a developmental program via neural stem cell-like intermediates.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Benedikt Berninger: Probing human neurogenesis by direct lineage re
 programming
URL:https://talks-calendar.ista.ac.at/events/1100
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