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DTSTART:20180325T030000
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DTSTART:20171029T020000
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BEGIN:VEVENT
DTSTAMP:20260424T143156Z
UID:5a26aafda412f755185356@ist.ac.at
DTSTART:20180226T133000
DTEND:20180226T144500
DESCRIPTION:Speaker: Xiaoke CHEN\nhosted by Simon Hippenmeyer\nAbstract: A 
 major challenge for successfully treating addiction is to prevent relapse\
 , which is largely due to the powerful memories associating drug-evoked ex
 periences with proximal environmental cues.  Immediate effects of drugs of
  abuse are followed by the emergence of a negative withdrawal state as the
  drug is metabolized.  Both positive reinforcement of drug reward and nega
 tive reinforcement of avoiding drug withdrawal promote the formation and m
 aintenance of drug-associated memories. The extent to which each of these 
 opponent processes contributes to drug seeking\, however\, remains elusive
 .  In this talk\, I will present evidence for supporting the essential rol
 e of the paraventricular nucleus of the thalamus (PVT) to the nucleus accu
 mbens (NAc) pathway in mediating opioid withdrawal symptoms. The identific
 ation of neuronal pathway for withdrawal provides unique opportunity to un
 tangle the respective contribution of reward vs. withdrawal process to dru
 g seeking.  I will discuss experiments using optogenetic pathway silencing
  to examine contribution of the PVT?NAc pathway to the acquisition and mai
 ntenance of opioid-associated memories\, and using this pathway as an entr
 y point to explore the brain wide network for storing opioid-associated me
 mories.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:cstreicher@ist.ac.at
SUMMARY:Xiaoke CHEN: Orchestrating opioid-associated memories in thalamic c
 ircuits
URL:https://talks-calendar.ista.ac.at/events/1097
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