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DTSTART:20180325T030000
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DTSTAMP:20260424T063052Z
UID:5a1ed46627f0b344605361@ist.ac.at
DTSTART:20180228T143000
DTEND:20180228T154500
DESCRIPTION:Speaker: Prof. Frank Bradke\nhosted by Simon Hippenmeyer\nAbstr
 act: Almost everybody who has seen neurons under a microscope for the firs
 t time is fascinated by their beauty and their complex shape.  Early on du
 ring development\, however\, neurons look round and simple without signs o
 f their future complexity.  How do neurons develop their sophisticated str
 ucture?  How do they initially generate domains that later have distinct f
 unctions within neuronal circuits\, such as the axon?  And\, can a better 
 understanding of the underlying developmental mechanisms help us in pathol
 ogical conditions\, such as a spinal cord injury\, to induce axons to rege
 nerate? Here\, I will talk about the cytoskeleton as a driving force for i
 nitial neuronal polarization and axon growth.  I will then explore how cyt
 oskeletal changes help to reactivate the growth program of injured CNS axo
 ns to elicit axon regeneration after a spinal cord injury.  Finally\, I wi
 ll discuss whether axon growth and synapse formation could represent mutua
 lly excluding processes.  Following this developmental hypothesis helps us
  to generate a novel perspective on regeneration failure in the adult CNS 
 and to envisage new paths to overcome it.   Thus\, this talk will describe
  how we can exploit developmental mechanisms to induce axon regeneration i
 n the adult after a spinal cord injury.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:wkoelbl@ist.ac.at
SUMMARY:Prof. Frank Bradke: Mechanisms of Axon Growth and Regeneration
URL:https://talks-calendar.ista.ac.at/events/1079
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