BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20180325T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20171029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260424T143002Z
UID:5a4b9f4b2102c073827983@ist.ac.at
DTSTART:20180221T100000
DTEND:20180221T110000
DESCRIPTION:Speaker: Peggy Wei\nhosted by Simon Hippenmeyer\nAbstract: Repa
 ir of DNA double strand breaks (DSBs) by the classical non-homologous end 
 joining (C-NHEJ) pathway is required for brain development. In mice\, neur
 al stem and progenitor cell (NSPC)-specific inactivation of C-NHEJ ligatio
 n complex in a p53-deficient background leads to medulloblastomas\, the mo
 st common and lethal pediatric brain cancer. To identify the source of DSB
 s\, we developed high throughput\, genome-wide\, translocation sequencing 
 (HTGTS) to map DSBs in base-pair resolution\, and found 113 recurrent DSB 
 clusters (RDCs) that occur in transcribed genes in murine NSPCs. The major
 ity of RDC-genes are involved in synaptic function and have genetic implic
 ations in brain development\, neuropsychiatric diseases\, and cancer. RDC-
 genes are generally very long with short exons\, and they often lie within
  topological associated domains (TADs). Frequent joining of intronic DSBs 
 coupling with exon loss is found in RDC-genes. Alternative spliced-like RD
 C-gene transcripts that encode such hard-wired gene templates were also id
 entified. We propose a new mechanism which could explain further neuronal 
 transcript diversification in development\, and its dysregulation to cause
  brain disease.
LOCATION:Big Seminar room Ground floor / Office Bldg West (I21.EG.101)\, IS
 TA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Peggy Wei: Recurrent Breaking Genes in Neural Stem and Progenitor C
 ells
URL:https://talks-calendar.ista.ac.at/events/1073
END:VEVENT
END:VCALENDAR