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DTSTAMP:20260424T141100Z
UID:5a4ccf01d49d1813283983@ist.ac.at
DTSTART:20180227T100000
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DESCRIPTION:Speaker: Maria Antonietta Tosches\nhosted by Gaia Novarino\nAbs
 tract: The stunning complexity of the brain\, with its myriad of cell type
 s and circuits\, is nothing but the result of the evolutionary process. St
 udying brain evolution can thus provide general insights on brain organiza
 tion and function.The cerebral cortex underwent a dramatic expansion and d
 iversification in vertebrate evolution. With its six layers\, the neocorte
 x is a mammalian novelty that supports higher cognitive functions. By cont
 rast\, the cortex of reptiles has an ancestral three-layered organization.
  Do these anatomical differences obscure deeper similarities\, visible onl
 y at cellular and molecular levels? To address this\, we profiled cell typ
 es in the reptilian cortex with large-scale single-cell mRNA sequencing. I
 n this presentation\, I will illustrate how the quantitative comparison of
  single-cell transcriptomes across species elucidates the evolution of neo
 cortex\, hippocampus and amygdala\, brain regions involved in learning and
  memory\, spatial navigation and fear. This analysis leads to new hypothes
 es on the evolution of cortical development and function\, which will be t
 ested in the future with single-cell profiling and genome editing tools.
LOCATION:Big Seminar room Ground floor / Office Bldg West (I21.EG.101)\, IS
 TA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Maria Antonietta Tosches: Evolution of the cerebral cortex at a sin
 gle-cell resolution
URL:https://talks-calendar.ista.ac.at/events/1070
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