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DTSTART:20180325T030000
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DTSTART:20171029T020000
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DTSTAMP:20260424T193043Z
UID:5a532fb7981c3904857029@ist.ac.at
DTSTART:20180301T100000
DTEND:20180301T110000
DESCRIPTION:Speaker: Mario de Bono\nhosted by Peter Jonas\nAbstract: We aim
  to discover molecular mechanisms that underpin neuron and circuit propert
 ies. As entry points we identify mutants in the nematode C. elegans unable
  to adopt particular behavioral states. Forward genetics is a potent tool 
 for discovering biological mechanism. However\, linking phenotypes to muta
 tions requires laborious mapping. We circumvent this by showing that bioin
 formatics alone can predict phenotype-causing mutations in large collectio
 ns of sequenced mutants. From 251 mutants defective in C. elegans aggregat
 ion behavior\, we identify (thus far) 43 genes promoting this behavior. Th
 e proteins they encode define several molecular machines. All act in the s
 ame defined circuit. I will describe some of our discoveries. Unexpectedly
 \, we find that interleukin 17\, a pro-inflammatory cytokine\, can act on 
 neurons to change circuit gain. We identify complexes in the endoplasmic r
 eticulum that appear to control biogenesis of ion channels and GPCRs. Thes
 e complexes are conserved\, and we are using biochemistry to understand th
 eir function in mammalian cells.
LOCATION:Big Seminar room Ground floor / Office Bldg West (I21.EG.101)\, IS
 TA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Mario de Bono: Discovering molecular nuts and bolts in the nervous 
 system
URL:https://talks-calendar.ista.ac.at/events/1063
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