BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20180325T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20171029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260407T011917Z
UID:5a1d5561632bc829652572@ist.ac.at
DTSTART:20180125T100000
DTEND:20180125T110000
DESCRIPTION:Speaker: Alexis Lomkin\nhosted by Michael Sixt\nAbstract: The m
 icroscopic environment inside a metazoan organism is highly crowded\, whic
 h makes free space a factor hindering the ability of cells to travel dista
 nces or expand the tissue that they build. To cope with this\, cells must 
 be able to measure the degree of spatial confinement and adapt their dimen
 sions and behaviors to the available space. Here\, we found that cells est
 imate externally-imposed confinement using their largest and stiffest intr
 acellular component\, the nucleus. Cell confinement below a certain thresh
 old compresses the nucleus and expands its envelope area. Unbuffered again
 st area expansion due to slow turnover of constituents\, the nuclear envel
 ope becomes stretched. This in turn engages signaling via nuclear membrane
  stretch-sensitive proteins to the actomyosin cortex\, whose vigorous cont
 ractions allow cells to minimize their surface and escape the confinement.
  This mechanism reveals a hitherto unappreciated non-genetic role of the n
 ucleus in guiding cell behaviors when surrounding space becomes restrictiv
 e. The advantage of the proposed mechanism is that in contrast to the plas
 ma membrane\, nuclear membranes do not participate in constitutive membran
 e trafficking\; their surface area thus fluctuates less. This intrinsic qu
 iescence should privilege them to function as low-noise detectors\, to rea
 dily discriminate local environmental conditions from internal traffic-ind
 uced cell area/tension fluctuations.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Alexis Lomkin: How cells sense their 'personal space': A role for n
 uclear deformations
URL:https://talks-calendar.ista.ac.at/events/1059
END:VEVENT
END:VCALENDAR