BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20180325T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20171029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260424T062936Z
UID:5a58bb98cab2d726237574@ist.ac.at
DTSTART:20180206T110000
DTEND:20180206T120000
DESCRIPTION:Speaker: Ivan Yudushkin\nhosted by Martin Loose\nAbstract: Sign
 aling networks orchestrate cellular responses to signals from the environm
 ent. To ensure the fidelity of these responses\, the cells need to precise
 ly position signaling enzymes at specific compartments and provide mechani
 sms to trigger and quench their activities in time. Yet\, the details of c
 ellular biochemical architecture and coupling between the location and reg
 ulation of signaling enzymes are not well understood.Using the most recent
  results from the lab\, published last year in Molecular Cell and JCB\, Iv
 ans talk will illustrate how a combination of in vitro biochemistry\, micr
 oscopy and fluorescence (cross-)correlation spectroscopy (FCS/FCCS) shed l
 ight on regulation of the protein kinase Akt and its activating complex mT
 ORC2 in cells. The results from Ivans lab demonstrate that the activities 
 of Akt and mTORC2 in cells are limited to cellular membranes\, ensuring th
 at they remain proportional to the upstream signals. Ivan will further dis
 cuss the principles of regulation of cellular enzymatic networks.Reference
 s:* Ebner et al PI(3\,4\,5)P3 Engagement Restricts Akt Activity to Cellula
 r Membranes (2017) Molecular Cell 65: 416-431* Ebner et al Localization of
  mTORC2 Activity In Cells (2017) J Cell Biol 216: 343-353* W: yudushkinlab
 .org
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:mloose@ist.ac.at
SUMMARY:Ivan Yudushkin: Biochemistry Illustrated: Observing signaling enzym
 es in their natural habitat
URL:https://talks-calendar.ista.ac.at/events/1045
END:VEVENT
END:VCALENDAR