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DTSTART:20180325T030000
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BEGIN:VEVENT
DTSTAMP:20260407T011844Z
UID:1516710600@ist.ac.at
DTSTART:20180123T133000
DTEND:20180123T143000
DESCRIPTION:Speaker: Yves Jossin\nhosted by Simon Hippenmeyer\nAbstract: Th
 e cerebral cortex is composed of different types and sub-types of neurons 
 that accumulate into 6 layers according to their birth date. These layers 
 are connected with other neurons inside and outside the cortex. Excitatory
  neurons are born in a region called the ventricular zone and migrate firs
 t as bipolar cells to the intermediate zone where they initiate a multipol
 ar migration (slow and characterized by frequent changes in direction). Th
 en neurons resume a bipolar migration (fast and unidirectional) towards a 
 region of the cortex called the cortical plate where they form synapses wi
 th each other. The Reelin signaling pathway is important for cortical orga
 nization\, dendrite growth and synaptic function. As such\, it has been in
 volved in lissencephalies\, schizophrenia\, epilepsy and autism. During em
 bryonic development\, absence of Reelin results in improper layering of th
 e cerebral cortex and other structures of the nervous system. The very fir
 st steps of the signaling cascade are already known. Its mechanism of acti
 on\, however\, still remains elusive. We recently demonstrated that Reelin
  mediates a new polarizing function that affects multipolar neuronal migra
 tion at the intermediate zone by regulating Rap1 which in turn regulates N
 -Cadherin. Cadherins are homophilic receptors involved in cell to cell adh
 esion. Today I will present some of our recent data suggesting a mechanism
  of action for N-Cadherin in the regulation of neuronal migration that doe
 s not depend on its homophilic adhesive property.
LOCATION:Lab East\, Seminar room / Ground floor\, ISTA
ORGANIZER:Waltraud Kölbl
SUMMARY:Yves Jossin: Non Adhesive Function of N-cadherin During Neuronal Mi
 gration
URL:https://talks-calendar.ista.ac.at/events/1038
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