TGF-ß signal dispersal during early vertebrate development
Date
Wednesday, December 6, 2017 10:30 - 11:45
Speaker
Patrick Müller (Friedrich Miescher Laboratory Tübingen)
Location
Meeting room 2nd floor / Bertalanffy Bldg. (I04.2OG - LAB)
Series
Seminar/Talk
Tags
Life Sciences Seminar
Host
Carl-Philipp Heisenberg
Contact
The secreted TGF-ß superfamily signals Nodal and BMP coordinate the patterning of vertebrate embryos: Nodal patterns endoderm and mesoderm during germ layer formation, and BMP induces ventral fates. Several theories have been proposed to explain how the correct distribution of Nodal and BMP signals is achieved within tissues, but the underlying biophysical assumptions have not been fully tested. I will present our recent quantitative experiments and mathematical modeling to elucidate the mechanisms controlling the spatial regulation of TGF-ß signaling during early vertebrate embryogenesis.