We introduce a Weyl functional calculus for the Ornstein-Uhlenbeck operator L=−Δ+x⋅∇, and give a simple criterion for Lp-Lq boundedness of operators in this functional calculus. It allows us to recover, unify, and extend, old and new results concerning the boundedness of exp(−zL)as an operator from Lp(ℝd,γα) to Lq(ℝd,γβ) for suitable values of z∈ℂ with ℜz>0 and α,β>0. Here, γτ denotes the centred Gaussian measure on ℝd with density (2πτ)−d/2 exp(−|x|2/2τ).