Let $W$ be an $N\times N$ Wigner matrix and $D$ a self-adjoint deformation of the same size. It is known that for large $N$, the resolvent $G(z)=(W+D-z)^{-1}$ of the deformed Wigner matrix $W+D$ concentrates around its deterministic approximation already for $z$ just slightly above the real line. This concentration phenomenon also extends to the products of multiple resolvents, such as $G(z_1)BG(z_2)$ for a deterministic matrix $B$. Such results are called the multi-resolvent local laws. In our work we extend this framework by proving the 2-resolvent local law for $G_1(z_1)BG_2(z_2)$, where $G_1$ and $G_2$ are resolvents of two differently deformed Wigner matrices $W+D_1$ and $W+D_2$. In the talk we will discuss two applications of this result. The first one addresses the sensitivity of a quantum evolution to perturbations via studying the so-called Loschmidt echo, while the second one studies the decorrelation of eigenvectors of $W+D_1$ and $W+D_2$. The talk is based on a joint work with G. Cipolloni, L. Erd{\H o}s and J. Henheik.