Institute Colloquium: Cell polarization in cell migration
Date
Monday, April 28, 2014 16:30 - 17:30
Speaker
Tobias Meyer (Stanford University)
Location
Raiffeisen Lecture Hall, Central Building
Series
Colloquium
Tags
Institute Colloquium
Contact
Url
I will be presenting our recent work using live cell fluorescence imaging to understand the molecular basis of polarization in mammalian cells. Particularly, I will be talking about cells that migrate on their own and cells that migrate collectively. Our recent work suggests that a core control element based on Cdc42 is particularly important for polarization and directed migration. In addition, cells can make use of additional supportive signaling mechanisms based for example on the lipids PIP3 and diacylglycerol. Finally, I will be discussing some of our recent results on how follower endothelial cells make use of mechanical cues to establish polarity with the cells ahead.