The Institute Colloquium: Protein evolution and protein engineering
Date:
Monday, June 24, 2013 16:30 - 17:30
Speaker:
José Manuel Sanchez Ruíz (Universidad de Granada)
Location:
Raiffeisen Lecture Hall, Central Building
Series:
Institute colloquium
Contact:
Hetzenauer Irene
Laboratory resurrection of ancestral proteins has been shown to provide insight into the ancient properties of biomolecules as well as the intracellular and extracellular environments hosting these proteins (1-3). Recently, laboratory resurrection efforts have been reported to successfully target billion years old Precambrian nodes in the evolution of several proteins (4-6). The characterization of laboratory resurrections of Precambrian proteins in terms of structure, stability and function will be described. The biotechnological potential of the extreme properties found for some resurrected Precambrian proteins (such as hyperstability and enhanced promiscuity) will be discussed.