The Institute Colloquium: Protein evolution and protein engineering
Date
Monday, June 24, 2013 16:30 - 17:30
Speaker
José Manuel Sanchez Ruíz (Universidad de Granada)
Location
Raiffeisen Lecture Hall, Central Building
Series
Colloquium
Tags
Institute Colloquium
Contact
Laboratory resurrection of ancestral proteins has been shown to provide insight into the ancient properties of biomolecules as well as the intracellular and extracellular environments hosting these proteins (1-3). Recently, laboratory resurrection efforts have been reported to successfully target billion years old Precambrian nodes in the evolution of several proteins (4-6). The characterization of laboratory resurrections of Precambrian proteins in terms of structure, stability and function will be described. The biotechnological potential of the extreme properties found for some resurrected Precambrian proteins (such as hyperstability and enhanced promiscuity) will be discussed.