The Institute Colloquium: Shedding light on synapse formation
Date:
Monday, April 29, 2013 16:30 - 17:30
Speaker:
Stephan Sigrist (Freie Universität Berlin)
Location:
Raiffeisen Lecture Hall, Central Building
Series:
Institute colloquium
Contact:
Hetzenauer Irene
Synapses process and store information, and might be a target for aging and neurodegenerative processes in our brains. Our group established protocols to directly visualize protein dynamics during synapse assembly and plasticity in living animals (Drosophila larvae) using confocal microscopy, and adapted high-resolution light microscopy (stimulated emission depletion microscopy, STED) for the analysis of synapse substructures. Data on the protein architectures organizing the synaptic vesicle release process at presynaptic terminals, as well as on the coordinated assembly of pre- and postsynaptic specializations, will be presented.