Five open questions about dendritic inhibition (I) will be discussed.
(i) Why I is distributed over the whole dendritic tree, far from the axonal output?
(ii) Why I on very distal branches?
(iii) Why different I-subclasses (basket, Chandelier, bi-tufted, etc.) cover different
dendritic subdomain of its target neuron and why each I-axon often makes there
1020 synapses?
(iv) Why, the 1/5 ratio between I/E in neocortex and hippocampus?
(v) Why do interneurons so reach in their firing repertoire? This analytical and
modeling study provides new and counterintuitive insights into the effect of
dendritic inhibition in controlling dendritic excitability and plasticity and in
molding the neurons output.