Parasites are assumed to evolve to optimise their exploitation of hosts, while hosts
evolve to minimize the damage done by the parasite. In coevolutionary models of
this process high specificity in host parasite interactions are assumed. Furthermore,
coevolutionary models make strict assumptions about the underlying genetics. Little
is known about the genetic interactions between hosts and parasites. In the Daphnia
system this can be conveniently addressed experimentally. Daphnia reproduce
clonally in the laboratory and clones can be crossed to test for segregation of
resistance loci. I present experimental data from our work on the genetics of
resistance against two parasites of Daphnia magna: the bacterium Pasteuria ramosa
and the microsporidium Hamiltosporidium tvaerminnensis. These parasites are
virulent and common to D. magna population in Europe. In natural populations
these parasites coevolve with their host. Using QTL mapping, de novo genome
sequencing and classical breeding experiments, I present our insights into the
nature of the genetics of antagonistic coevolution.