Molecular function of chromatin regulators in neurodevelopment and diseases
Date
Monday, February 13, 2017 15:00 - 16:00
Speaker
Kyung-Min Noh (The European Molecular Biology Laboratory)
Location
Seminar Room, Lab Building East
Series
Seminar/Talk
Tags
Life Sciences Seminar
Host
Gaia Novarino
Contact
Chromatin, the devoted association of histone proteins and genomic DNA, exists as the physiological form of our genome and the substrate for chromatin regulators (e.g. writer, eraser, leader) that orchestrate gene expression. Recent advances in genome sequencing have made it clear that mutated chromatin regulators increase susceptibility to neurodevelopmental disorders. Given that it is often unknown how such mutations lead to abnormal function within the cells, our lab is working to elucidate the normal and pathological mechanisms of the chromatin regulators. I will present our past and current works in neurodevelopmental disorder linked chromatin regulators, ATRX and RAI1.