Understanding Ras Sensitivity to Mutation by High-Throughput Mutagenesis
Date
Tuesday, June 4, 2019 14:00 - 15:30
Speaker
John Kuriyan (Howard Hughes Medical Institute Departments of Molecular & Cell Biology and Department of Chemistry, UC Berkely)
Location
Big Seminar room Ground floor / Office Bldg West (I21.EG.101)
Series
Seminar/Talk
Tags
Life Sciences Seminar
Host
Florian Schur
Contact
Ras and many other proteins that are oncogenic, i.e., associated with cancer when mutated, are allosteric switches. The growing power of gene synthesis and next-generation sequencing can be harnessed to yield insights into molecular mechanism in a novel way. I will cover the application of high-throughput mutagenesis to Ras, combined with structural analysis and molecular dynamics simulations, with an emphasis on understanding the allosteric mechanisms that lead to mutational sensitivity.